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A team of specialists led by ���ϳԹ��� of ���ϳԹ��� medical researchers have performed Pitt and UPMC’s first in utero surgery to close an open neural tube defect in a baby months before her birth. 

“This surgery is risky, but research shows that babies who are closed in utero have better neurologic outcomes than babies treated after birth,” said , associate professor of , who was part of the surgical team.

When Allee Mullen was pregnant, her baby was diagnosed with , a birth defect in which the baby is born with the spinal cord exposed to the air because the overlying bone, muscle and skin do not form properly during development, causing moderate to severe physical disabilities. There are several types of spina bifida, and Mullen’s baby was diagnosed with a myelomeningocele, the most serious form.

Spina bifida affects about 1,500 babies born each year in the United States. At UPMC Children’s Hospital, physicians close defects like this one in 10 to 20 infants each year following delivery. 

The in utero procedure has been performed at several centers across the United States but had not yet been available in the ���ϳԹ��� area. In January 2019, an interdisciplinary team of maternal-fetal medicine, obstetric anesthesiology, neonatology and pediatric neurosurgery specialists from Pitt, UPMC Magee-Women’s Hospital and UPMC Children’s Hospital performed and assisted during the complex surgery on Mullen and her unborn baby, who was at 25-weeks gestation at the time. 

A randomized controlled published in the New England Journal of Medicine in 2011 showed that, compared to surgery after birth, fetal surgery resulted in improved leg function and halved the risk for hydrocephalus — fluid buildup in the brain — a common complication of spina bifida.

“Being able to perform this surgery in utero offers many benefits to the baby, but one of the most important is improving the chances a child will be able to walk on their own,” said , associate professor of in Pitt’s School of Medicine.

Two months following the prenatal surgery, Mullen’s baby girl, Emery Greene Mullen, named after the lead surgeons, was born.

“Our initial tests show that Emery has almost entirely normal leg function. It can take up to a year to rule out hydrocephalus, but we are very hopeful. The neurologic outcome is definitely better than if her surgery had been done after birth,” said Greene, who is also the director of vascular neurosurgery at Children’s Hospital of ���ϳԹ���.

“Pregnant women diagnosed with fetal spina bifida might very well be candidates for the in utero procedure,” said Emery. “We are excited and proud to now offer this service at UPMC Magee to patients living in the western Pennsylvania and tri-state regions.”

“To be the first patient in ���ϳԹ���, I hope mothers will learn about my story and the hope for Emery’s future, and if they are in the same position as me, they will know there is an option and it is close to home,” said Allee Mullen. “I thank Dr. Emery, Dr. Greene and the entire team for what they did for Emery and our family.”

For more information on procedures like this one, visit UPMC’s ���ɱ���貹����.